Cytodifferentiation Effects of Zinc in Vivo

Résumé du livre

We also show by flow cytometric quantitation of DNA content in control and zinc-treated Chang liver cells (0.4 uM zinc chloride) that there is no inhibition of DNA synthesis in zinc treated cells as measured by the Coulter "EPICS PROFILE ANALYZER". At higher dosages, 3-10 mM zinc chloride does inhibit DNA synthesis in human Chang liver cells and Cloudman mouse melanoma cells (bay & Sit, Tohoku J, Exp. Med. 1992; 168:63-69). Therefore, although zinc is involved in more than 235 metalloenzymes including thymidine kinase, RNA polymerase and ribonuclease, which in turn play a crucial role in the replication and transcription of DNA during cell division, it would apper that there are other mechanisms apart from cell proliferation causing the effects observed here (Bay & Sit, Singapore Med. J. 1993; 34:58-59). [Authors' abstract].