Kinetics of the Inflammatory Response During Experimental Babesia Rossi Infection of Beagle Dogs

Résumé du livre

Objective: To compare the effect of invasive continuous positive airway pressure (CPAP), pressure-controlled ventilation with positive end expiratory pressure (PCV+PEEP) and spontaneous breathing (SB) on carbon dioxide removal, blood oxygenation and indicators of tissue perfusion in healthy anaesthetised dogs. Study design: Prospective randomised crossover study. Animals Fifteen intact male dogs of various breeds of mean (± standard deviation) age and weight of 25 (± 19) months and 21.7 (± 9.9) kg, respectively. Methods Dogs were anaesthetised (buprenorphine, medetomidine, propofol) and maintained with isoflurane in 50% oxygen-air mixture and kept in right lateral recumbency. Ventilation treatments (CPAP: 4 cmH2O; PCV+PEEP: 10 cmH2O peak inspiratory pressure, 4 cmH2O positive end-expiratory pressure, respiratory rate of 10 breaths minute-1 and inspiratory-to-expiratory ratio of 1:2; SB: standard circle circuit, no pressure applied) were administered to each dog consecutively in random order under the same anaesthetic period with 5-minute SB washout period between treatments. Arterial and central venous blood samples for gas analysis were collected at the start (0 minutes) and end (20 minutes) of each ventilation treatment. Arterial to venous content difference was calculated for each ventilatory treatment. Other physiological variables and spirometry measures were collected at 5-minute intervals from start to end for each ventilation treatment. Data was compared using a general linear mixed model (p