Studies on the Existence of an Independent Brain Renin-angiotensin System

Résumé du livre

"An enzyme, capable of catalyzing the reaction with renin substrate to form angiotensin is described in the brain of dogs, rats, sheep and man. This brain tissue iso-renin differs in important characteristics from renal renin. The enzyme persists at control-levels 12 days after nephrectomy. Renin substrate has been found equally in brain tissue of dogs. Angiotensin was extracted from brain of dogs which had been nephrectomized and in which plasma angiotensin was undetectable. This shows that angiotensin can be formed locally in the brain. An iso-renin of similar characteristics as brain iso-renin is described and partially characterized in aortic tissue and in adrenal glands. The independence of tissue iso-renin from kidney renin is supported by the fact that the two enzymes react differently to the same physio-pathological stimuli."--