The Application of Robust Calibration to Radioimmunoassay
Auteur : Marcello Pagano, James Julius Tiede
Date de publication : 1977
Éditeur : State University of New York at Buffalo, Department of Computer Science, Statistical Science
Nombre de pages : 36
Résumé du livre
In this paper, a new approach to the analysis of RIA data is discussed. An algorithm is presented for obtaining the M-estimates of nonlinear calibration curves. The curves to be fitted are modified hyperbolae based on 12 to 16 observations. A procedure, based on the application of the Bonferroni Inequality, is presented for obtaining tolerance-like interval estimates of the concentration of the hormone of interest in the patients. Results of simulations are cited to support the method of construction of confidence bands for the fitted calibration curve. Data obtained from the Veteran's Hospital, Buffalo, New York are used for examples throughout the paper. (Author).