(+)-AVERUFIN: TOTAL SYNTHESIS AND ROLE IN THE BIOSYNTHESIS OF AFLATOXIN B(1).

Résumé du livre

(+)-Averufin was synthesized in 11 steps starting from resorcinol. An intermediate alcohol was submitted to optical resolution through its (-)-MTPA esters. The absolute configuration of the resolved products was determined by the dibenzoate chirality rule: one of the optically active products was converted to a cyclic dibenzoate, the configuration of which was determined by circular dichroism. By chemical correlation, the absolute structure of averufin was thus determined unambiguously. The biosynthetic