Antilipidemic Drugs

Résumé du livre

Clearly, a major disorder of these times is Coronary Heart Disease (CHD) with atherosclerosis being the underlying cause. The biochemistry of this multifaceted disease of lipid and lipoprotein metabolism, our understanding of atherogenesis, and the medicinal chemical basis of antilipidemic and antiatherogenic organic chemicals have recently undergone major advances. These advances, the major epidemiological studies and drug trials involved, are well reflected in this book, along with information demonstrating treatment efficacy of diet and pharmaceuticals in both animal and clinical trials and a mechanism-based understanding of these treatment modalities. The physiology and pathophysiology of lipid and lipoprotein metabolism and the relationship of the underlying metabolic processes to the development of the atherosclerotic plaque are also covered, as are many more topics in this extensive treatize. The 17th volume in this well-known series, it provides up-to-date coverage of the medicinal, chemical and biochemical aspects of antilipidemic drugs.